A modular and reconfigurable hardware platform for analog optoelectronic signal acquisition is presented. Its intended application is for fiber optic sensing in electronic musical interfaces, however the flexible design enables its use with a wide range of analog and digital sensors. Multiple gain and multiplexing stages as well as programmable analog and digital hardware blocks allow for the acquisition, processing, and communication of single-ended and differential signals. Along with a hub board, multiple acquisition boards can be connected to modularly extend the system’s capabilities to suit the needs of the application. Fiber optic sensors and their application in DMIs are briefly discussed, as well as the use of the hardware platform with specific musical interfaces.